Balboa Boulevard is a major north–south street in the city of Los Angeles, and it cuts through many communities and is one of the main thoroughfares in the San Fernando Valley.

Several of the San Fernando Valley's north-south streets were originally named after historic explorers, including Balboa, De Soto, Alvarado, Cabrillo, Cortez, and Diaz, but Balboa Boulevard and De Soto Avenue are the only street names that remain.

Notable destinations on Balboa Blvd include (from south to north) Encino Chamber of Commerce, Children's Hospital Los Angeles outpatient specialty center, Sepulveda Dam Recreation Area, Lake Balboa Park, Valley Relics Museum, Knollwood Country Club, and Joseph Jensen Water Treatment Plant.

The Cascades, an important part of the Los Angeles Aqueduct, is also located near Balboa's northern terminus.

The G Line serves a station at its intersection with Victory Boulevard in Lake Balboa.