His notability as a construction engineer earned him the commission to carry out a detailed survey of Rome's city walls and those of the bastions at Ancona, Civitavecchia and Ostia, and for Pope Pius IV From 1557 he worked almost exclusively for Cosimo I de' Medici, Lanci's chief employer and patron for whom he supervised such projects as the fortification of Siena and many other Tuscan towns.
This is not to say Lanci was a man lacking in sophistication, one of his more surprising talents was designing some of the sets for the lavish theatrical and dramatical performances for which the Medici court was famed.
Long before the Restoration spectaculars of the 17th century Lanci was designing elaborate and complicated theatre sets, using pivoted scenery, with up to three different scenes painted on boards, thus allowing the mood of the production to be altered in an instant.
One of the earliest examples of this form of scenic change was recorded in 1568 for a performance of the Fabii produced to celebrate the baptism of a daughter of Francesco de' Medici.
What in fact Lanci realised and promoted was that a false perspective coupled with a deliberately created illusionary architectural area, was the perfect dramatical setting.