Operations are organized around six main commercial divisions: large corporations, SMEs, private clients, consumer finance, international banking and capital markets.

[citation needed] On December 9, 2004, Banco de Chile became the first Chilean financial institution to operate in the Asian markets, after closing a co-operation agreement with Standard Chartered Bank.

[citation needed] In 2005, the US Office of the Comptroller of the Currency (OCC) removed the General Manager of Banco de Chile - New York from the United States banking industry and imposed a $200,000 civil money penalty against the individual for engaging in unsafe banking practices, related to his involvement in accounts owned or controlled by the prominent politically exposed person and his associates.

The US Financial Crimes Enforcement Network also levied a $3 million penalty on Banco de Chile for not identifying, monitoring and reporting suspicious activity related to a Chilean politically exposed person, his family and associates doing business in its New York and Miami branches.

[2] In 2009, Banco de Chile was one of four banks sued by the Chilean government for negligently or deliberately helping former dictator Augusto Pinochet hide $26 million in stolen funds.