[1] The hospital was established in 1898 with the royal permission of King Chulalongkorn (Rama V) for the aim of providing of services for large number prostitutes in this area (Chinatown and Phlapphla Chai) in order to prevent the spread of epidemics.

During this time, it provided medical services to police officers and conducted autopsies from various cases.

At the same time, 36 beds were added for the treatment of prostitutes, following its initial intended purpose.

[2][3] On 13 June 2012, the Medical Services Department of the BMA signed an agreement to train medical students of the School of Medicine, Mae Fah Luang University at the hospital under the Collaborative Project to Increase Rural Doctor (CPIRD) Program.

Along with Charoenkrung Pracharak Hospital in Bang Kho Laem District, both hospitals form the Medical Education Center of the Medical Services Department, Bangkok Metropolitan Administration (MEC MSD BMA).