Among the first were country music star Carrie Underwood, comedian Jeff Dunham, and the cast of the reality television show So You Think You Can Dance as well as Cirque du Soleil, and the Walking With Dinosaurs live production.

Other artists/performers that have visited the arena include Alan Jackson with Jana Kramer, Barry Manilow, Bill Engvall, Jeff Foxworthy, and Larry The Cable Guy, Blake Shelton, Bob Dylan, Dane Cook, Jason Aldean, Luke Bryan, Martina McBride, Trace Adkins, Jay-Z, REO Speedwagon, and Styx among others.

[8][9] The Bank of Kentucky agreed to cover 10% of the cost of the arena, up to $6 million, in exchange for naming rights.

The Truist name was adopted for the arena shortly after the 2021–22 basketball season, taking effect on April 5, 2022.

[11] Beginning in spring of 2011, Truist Arena was home to the Northern Kentucky River Monsters of the Ultimate Indoor Football League.