[5][7] Its current headquarters, the Bank of Singapore Centre at Market Street which is located in the heart of Raffles Place, was officially opened on 22 June 2011.

In November 2016, Bank of Singapore received regulatory approval to operate a branch in Dubai International Financial Centre (DIFC).

On 19 October 2022, BOS Wealth Management Europe S.A., the Luxembourg-based European wealth management arm of Bank of Singapore, was fined €210,000 by Luxembourg’s financial regulator Commission de Surveillance du Secteur Financier (CSSF) for non-compliance with laws on the fight against money laundering and combatting the financing of terrorism.

[18][19] On 10 November 2022, the Dubai Financial Services Authority (DFSA) imposed a US$1.12 million fine on the Dubai International Financial Centre (DIFC) branch of Bank of Singapore for a number of contraventions, such as inadequate systems and controls, and shortfalls relating to anti-money laundering.

[20] DFSA found deficiencies in the bank's AML business risk assessments; assessment of risks posed by its clients; customer due diligence and enhanced customer due diligence practices; identification of clients' source of wealth and funds; and suspicious activity reporting.