Bosson was born in Charleroi, Pennsylvania, to a tennis coach father, and raised in the nearby coal-mining town of Belle Vernon.

[1] She later moved to New York and worked as a secretary for the American Conservatory Theater and as a Playboy Bunny while taking acting classes with Herbert Berghof and Milton Katselas.

[4] She later had a recurring role in the legal drama Civil Wars and guest-starred on Star Trek: Deep Space Nine (in episode "Rivals" as Roana), and Lois & Clark: The New Adventures of Superman.

From 1995 to 1997, Bosson starred as a tough prosecutor Miriam Grasso in the ABC legal drama series, Murder One, which earned her an additional Emmy Award nomination.

[3] In 1970, Bosson married writer-producer Steven Bochco, who created several of the series in which she starred, including Hill Street Blues, L.A. Law, Murder One, and Cop Rock.