The show centered on the professional and personal life of San Francisco police Inspector Harry Hooperman, played by John Ritter.
Due to the demands of his job as a police officer, he hires Susan Smith (played by Debrah Farentino) to be the building manager, and the pair become romantically involved throughout the first season.
Also starring on the show was Alix Elias as the cheerful and bubbly police dispatcher, Betty Bushkin; Barbara Bosson was Hooperman's divorced superior, Capt.
Stern; Felton Perry as Harry's partner, Inspector Clarence McNeil; Clarence Felder as redneck inspector Boris "Bobo" Pritzger; Joseph Gian as Rick Silardi, a gay cop, and Sydney Walsh as officer Maureen "Mo" DeMott, his patrol partner who was intent on "saving" him from being gay by making unwanted passes.
Guest stars in the series' 42-episode run included: Don Cheadle, Kim Delaney, Dennis Dugan, Norman Fell (who worked with Ritter on The Stone Killer and Three's Company), Miguel Ferrer, Jack Gilford, Mark Hamill, Joanna Kerns (who did a guest spot on Three's Company), Richard Kind, Dan Lauria, Jane Leeves, Lorna Luft, David Paymer, Barbara Rush, and Shannon Tweed.