She married in 1689 the much older Count Wolfgang Julius of Hohenlohe-Neuenstein, widower of Sophie Eleonore of Holstein-Sonderburg-Plön.
The legacy of her husband fell to his brother, John Frederick I of Hohenlohe-Öhringen; Franziska Barbara only received the Lordships of Wilhermsdorf and Neidhardswinden, which Wolfgang Julius had bought on 4 May 1667.
Three years later, in 1701, she married a 35-year-old second husband, Count Philip Ernest of Hohenlohe-Waldenburg-Schillingsfürst (born: 29 December 1663; died: 29 November 1759).
After Philip Ernest's death, was the fiefs Wilhermsdorf and Neidhardswinden fell to his underage children.
He, too, remained childless, so that in 1769 (or earlier), Wilhermsdorf fell to Philip Ferdinand of Limburg-Styrum, the son of Franziska Barbara's daughter Caroline Juliane.