[2] She was the Republican nominee for Colorado's 8th congressional district in the 2022 election, losing to Yadira Caraveo in a close race.

In the 2020 Republican primary election for Colorado's 23rd Senate district, Kirkmeyer defeated opponent Rupert Parchment, winning 55.24% of the votes cast.

[6] She currently serves on the Senate Education, Local Government, Health and Human Services, and Statutory Revision Committees.

[8] On June 28, 2022, she won the Republican primary and advanced to the November general election ultimately losing to Democratic opponent, Yadira Caraveo.

She is one of Colorado's most anti-abortion lawmakers, supporting banning the procedure and some forms of contraception and celebrating the overturning of Roe v.