Barbara was a daughter of Margrave Frederick the Elder of Brandenburg-Ansbach and Bayreuth (1460-1536) from his marriage to Sophia Jagiellon (1464-1512), daughter of King Casimir IV Jagiello of Poland.
She married on 29 September 1527 at the Plassenburg to Landgrave George III of Leuchtenberg (1502-1555).
[1] The marriage had been mediated by her brother Albert and was instrumental in restoring the financial health of the Landgraviate.
A red marble grave place with her coat of arms can be found in front of the altar.
[2] From her marriage, Barbara had the following children: This article about a member of the German nobility is a stub.