Schroeder started his career producing such films as The Bakery Girl of Monceau (1962), Six in Paris (1965), and Celine and Julie Go Boating (1974).

He directed what he labeled, "The Trilogy of Evil", which includes the films, General Idi Amin Dada: A Self Portrait (1974), Terror's Advocate (2007) and The Venerable W. (2016).

He later went on to direct more mainstream Hollywood fare, such as Barfly (1987) starring Mickey Rourke, Single White Female (1992) and Reversal of Fortune (1990), for which Jeremy Irons as Claus von Bülow received an Academy Award.

Despite his many commercially successful films, Schroeder continues to be interested in making smaller films with a more limited audience, such as the adaptation of Colombian writer Fernando Vallejo's controversial novel La virgen de los sicarios (2000) or the documentary General Idi Amin Dada: A Self Portrait (1974), featuring extensive interviews with the Ugandan dictator and Terror's Advocate (2007) about terrorism in the last fifty years, seen through the eyes of a lawyer, Jacques Vergès, and his clients.

[3] Schroeder directed the 12th episode of the third season of the American dramatic television series Mad Men that first aired on 1 November 2009.