Envisaged by the late His Highness Sir Sayajirao Gaekwad III as a seat of learning, Medical College Baroda and Shri Sayajirao General (SSG) Hospital was founded in the city of Vadodara by the late Maharaja of Baroda, Major General Sir Pratapsingh Gaekwad January 1946.

Due to the efforts of Dr. Jivraj Mehta, the then Advisor to Government of India and Bombay State on Baroda matters, the ground floor was completed in 1949.

For initial development, the institute was entrusted to the late D. A. N. Deodars – the first Dean and Medical Superintendent of S. S. G. Hospital.

Encircling the main college buildings there are separate buildings that house the postmortem room, the physiotherapy college, Departments of Surgery, Pediatrics, Orthopedic, Skin & V. D., Psychiatry and Obstetrics and Gynecology, Radiology, Radiotherapy and Urology.

The admission is done on a merit wise allotment after students clear the National Eligibility cum Entrance Test (NEET) examination.