As of January 2012, the station is used by about 700 passengers per day,[1] up from 350 at the time of its opening.

[5] The station's opening restored GO train service to Barrie, which had been eliminated in the 1990s.

Barrie South station has weekday train service consisting of 7 trains southbound to Union Station in the morning, and 7 trains returning northbound from Union Station in the afternoon.

At other times, GO bus route 68 operates hourly to Aurora GO Station where passengers can transfer to the all-day train service to Toronto.

GO bus route 68 also operates hourly to Aurora GO station or East Gwillimbury GO station where passengers can connect to the hourly weekend train service to Toronto.