The protein encoded by this gene was identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome.

The protein forms a homodimer which localizes to the nucleus and is specifically associated with chromosomes during mitosis.

The protein's DNA binding ability is modulated by ATP concentration.

[7] Barrier to autointegration factor 1 has been shown to interact with Thymopoietin.

[8] Mutations in this gene have been shown to cause hereditary progeroid syndrome.