His reports (dispacci) to Venice provide a unique historical source for southern Greece in the later 15th century, during the first decades of the Ottoman occupation.
[2] In 1462, Minio was a consiliere to the rettor of Corfu during his early career in the Stato da Màr, Venice's overseas colonies.
An edition of these letters by Diana G. Wright and John R. Melville-Jones, accompanied by a translation and commentary, has been published (2008) by UniPress, Padova, Italy.
In 1509, at the age of 80, he was sent to Julius II in order to discuss matters pertaining to the papal interdict placed on Venice for the capture of Ravenna and Faenza.
In the Bay of Biscay, the convoy of four galleys was attacked by pirates, one of whom was Christopher Columbus, the merchandise was taken, and Minio and the survivors left on the coast of Portugal.