Bartram explored much of the territory which is now the states of North and South Carolina, Georgia, Florida, Alabama, Mississippi, Louisiana and Tennessee.

The BTC also encourages the study, preservation and interpretation of the William Bartram heritage at both cultural and natural sites in Trail states.

From Warwoman Dell, it climbs again before dropping to its lowest elevations along a stretch of the Wild and Scenic Chattooga River.

In North Carolina, the Bartram Trail meanders 78.4 miles (126.2 km) near the mountainous towns of Franklin, Highlands, Andrews, Robbinsville, and Nantahala.

The William Bartram Arboretum (32°31′N 86°15′W / 32.51°N 86.25°W / 32.51; -86.25) is located within Fort Toulouse Park, near Wetumpka, Alabama and is named in honor of the 18th century naturalist, who visited the area in 1776.