The Basilica and Shrine of Our Lady of Perpetual Help (Latin: Basilicæ Minoris de Beatæ Maria Virginis de Perpetuo Succursu) informally known as The Mission Church is a Roman Catholic basilica in the Mission Hill neighborhood of Boston, Massachusetts, United States.

[4] Pope Pius XII raised the shrine to the status of Minor Basilica via his Pontifical Decree Ornatur Urbs et Archidiocesis on September 8, 1954, which was signed and notarized by the Grand Chancellor of Apostolic Briefs, Monsignor Gildo Brugnola.

Pleased with the success of the mission, Father Healy recommended to the Bishop that the religious congregation should establish a mission-house in Boston.

This was to serve as a "mission house", a home base for priests traveling to distant parts of Massachusetts, Canada, and elsewhere.

Frawley began a quarterly publication, The Little Messenger of Mary, which included among other features, accounts of favors received at the shrine.

[9] An account of the sick flocking to the shrine was published in the New York Herald in March 1901, under the headline "A Lourdes in the Land of Puritans".

During World War I, the Roxbury shrine became popular with family members praying for the safe return of soldiers.

With 24 classrooms to accommodate 1,200 pupils, the School Sisters of Notre Dame arrived from Baltimore to begin the new endeavor of educating the parish's boys and girls.

The building was sold to the Boston Public School system and continues to be operated today as New Mission High.

[11] In 1900, St. Alphonsus Hall was opened as an early form of community center to serve a large immigrant population, most notably from Ireland.

With an all female cast, the fictitious drama centers around the daughter of Pilate, Claudia, who threw a rose at Christ as he passed by carrying his cross.

[8] The rectory also served as a house of formation for Redemptorist seminarians studying at Boston College and St. John's Seminary in Brighton until August 2017.

The basilica is located on Tremont Street, almost at the center of Mission Hill, a 0.75-square-mile (1.9 km2)[12] Boston neighborhood of approximately 18,000 people.

He had often prayed at the church due to its proximity to the hospitals in the Longwood Medical Area of Boston, where he had visited sick and injured members of his family.