The design of the church is attributed to Angelo Italia (1628–1700), who changed the orientation of the previous edifice destroyed by the earthquake, in order to have it facing the new via Uzeda (current Etnea Street) according to the new urban plan for the city.

The façade, designed by Polish architect Stefano Ittar (1724–1790), is one of the most notable examples of late Baroque in Catania.

In the south corner of the church, abutting the apse on via Manzoni, is a small two retail outlet building, Negozio Frigeri, designed in 1909 by Tommaso Malerba in Liberty style.

In the apse of the nave is the high altar, with an icon of the Virgin with a Child, a copy of a Byzantine original in the sanctuary of Biancavilla.

The left aisle, in the apse area, houses the Holy Sacrament Chapel, with a polychrome marble altar.