The Basilica of San Francesco is a late Medieval church in Arezzo, Tuscany, Italy, dedicated to St Francis of Assisi.

It is especially renowned for housing in the chancel the fresco cycle Legends of the True Cross by Piero della Francesca.

At the chancel entrance is suspended a very large painted rood crucifix by one Master of San Francesco, a contemporary of Cimabue.

The Cappella Maggiore, (Major Chapel or chancel) houses one of the masterworks of Italian Early Renaissance, a fresco cycle by Piero della Francesca depicting the Legend of the True Cross.

Piero della Francesca did not follow a chronological order, preferring to concentrate himself in the creation of symmetrical correspondences between the various scenes.