The Battle of Sedjenane was fought during World War II between the Allies and Axis for control of a town in northern Tunisia, on the railway line to Mateur and the port of Bizerta.

British troops of the 8th Battalion, Argyll and Sutherland Highlanders, part of 36th Brigade of British 78th Division, were ambushed as they advanced on the road through the hills on November 29, 1942, and their wrecked Universal Carriers in No man's land became a grim symbol of the ensuing stalemate to Allied troops over the following several months of the Tunisia Campaign.

Alan Moorehead a war correspondent wrote in African Trilogy (1944), Sejenane was a wayside railway town in the wet cork forests on the way to Mateur.

In a subsidiary operation Unternehmen Ausladung, the Axis attempted to outflank the British troops in Sedjenane and on the high ground opposite "Green Hill", with an attack on the hilly coastal strip to the north between the town and Cap Serrat, which was only lightly held by poorly-equipped French troops of the Corps Francs d'Afrique.

According to Associated Press war correspondent Don Whitehead, an Italian infantry battalion (from the 10th Bersaglieri Regiment) supported by 30 tanks counterattacked in the British sector on 3 March, but lost half its strength killed to machine-gun fire.