While Shire had been at the forefront of the conflict since 2020, the October 2022 offensive towards the town solidified Ethiopian and Eritrean control over it, and was the last major battle before peace negotiations began that November.

[11][12] During the offensive, locals in central Tigray region claimed trucks filled with wounded civilians and soldiers were coming from the frontlines into TPLF-controlled areas.

[1] United Nations Security Chief Samantha Power stated that Ethiopian troops were launching "indiscriminate attacks" on the town during the battle.

[17] Locals in Shire claimed that immediately after the capture of the town, the entire population was starving, including aid workers and humanitarian assistance.

[20] World Health Organization chairman Tedros Adhanom Ghebreyesus, a Tigrayan native, warned that Ethiopian forces were carpet-bombing whole cities in the region.

[22] The success of the Ethiopian forces in Shire opened negotiations a second time, with a peace deal being signed ending the Tigray War on 2 November.

[23] From 17–23 November alone, Eritrean forces killed 111 civilians in Eritrean-controlled areas of Tigray region, and over 200 hourses were destroyed, including in Shire.

[25] Shire residents interviewed by PBS stated that there were two separate detention centers run by Eritrean forces following the battle, and that at one point "more than 300" youths were rounded up and sent to one.