Dam walls at the end of the bayou were closed to prevent a storm surge of salt water from entering.

The leak was caused by a valve failure at a Crescent Midstream crude oil facility and the resulting discharge travelled into the bayou from a storm drain.

[12][13] In 2016, Bayou Lafourche was dredged from Donaldsonville to Napoleonville of vegetation and sediment that constricted the surface area of the water.

"[16] In The CW Network's supernatural-fantasy series, The Originals, the Bayou Lafourche is a major setting and has acted as the home of the Werewolf encampments for decades after the Vampires exiled them from the city of New Orleans.

In the film Hard Target, the lead character Chance Boudreaux, played by Jean-Claude Van Damme, is a Cajun from Bayou Lafourche in Southern Louisiana.