Transcontinental Drive began as a main thoroughfare through the Bridgedale subdivision, which opened in 1925 during construction of the Airline Highway between Shrewsbury and Kenner.

Transcontinental Drive was intended to be extended south to Jefferson Highway (State Route 1) to connect with the Huey P. Long Bridge then in the planning stages.

These plans never came to fruition, and the Bridgedale area would not be not directly connected to the bridge for almost fifty years via an extension of Clearview Parkway.

[6] The route initially heads north on Hickory Avenue, an undivided two-lane thoroughfare, from LA 48 (Jefferson Highway) in Harahan.

At Roberts Street, signs direct traffic onto Dickory Avenue, a parallel divided four-lane thoroughfare, to continue north on LA 3154.

The route originally followed Hickory Avenue for its entire length and crossed what was then the Illinois Central Railroad (IC) line at grade.

Construction began in 1974 on a four-lane bypass of Hickory Avenue that would include a railroad overpass and an interchange with the future Earhart Expressway.

Almost two decades later, Dickory Avenue was extended slightly to the south, providing better access to the Elmwood Business Park.

Plans are underway to extend the road to Jefferson Highway and bypass the remainder of Hickory Avenue.

[7] It crosses the Canadian National Railway line at grade at its southern end and is an undivided two-lane highway for its entire length.

Little Farms Avenue was soon extended across the railroad tracks to connect with the newly constructed Airline Highway.

[9] In 1954, the Bunche Village residential subdivision opened adjacent to Little Farms Avenue between the railroad tracks and Airline Highway.

The 0.21-mile-long (0.34 km) highway begins at West St. Peter Street (carrying eastbound LA 182) and travels northeast past a church, school, and a house.

[16] The route connects Hahnville, the parish seat, with LA 3127, a highway constructed in the 1970s that bypasses the various communities along the west bank of the Mississippi River between Luling and Donaldsonville.

Louisiana Highway 3168 (LA 3168) runs 0.67 miles (1.08 km) in a north–south direction from US 90 to a point just south of I-10 in Scott, Lafayette Parish.

Upon reaching a roundabout intersection with St. Mary Street, the town's main north–south thoroughfare, the LA 3168 designation ends.

Louisiana Highway 3173 (LA 3173) runs 1.26 miles (2.03 km) in a general north–south direction through Krotz Springs, St. Landry Parish.

It then turns north onto 9th Avenue, crosses the Union Pacific Railroad (UP) tracks, and intersects LA 3174 (Main Street).

Louisiana Highway 3174 (LA 3174) runs 0.92 miles (1.48 km) in an east–west direction along Main Street in Krotz Springs, St. Landry Parish.

Louisiana Highway 3178 (LA 3178) runs 0.23 miles (0.37 km) in an east–west direction along Florida Street in Krotz Springs, St. Landry Parish.

It provides a more direct connection between US 190 and LA 105 at the west end of the Krotz Springs Bridge over the Atchafalaya River.

[39] It is a largely commercial corridor that connects I-10 with Cajun Field, the Cajundome Convention Center, and Lafayette's southwest suburbs.

The route heads northwest on Bertrand Drive from LA 3025 then curves due north onto Ambassador Caffery Parkway.

Louisiana Highway 3188 (LA 3188) runs 2.80 miles (4.51 km) in a north–south direction from US 61 to I-10 in LaPlace, St. John the Baptist Parish.

[43] LA 3188 heads north from US 61 (West Airline Highway) on Belle Terre Boulevard, a divided four-lane commercial thoroughfare.

There are four signalized intersections along the route: US 61, a shopping strip entrance, Fairway Drive, and St. Andrews Boulevard.

The highway curves to the northeast, engaging in a trumpet interchange with I-10 at Exit 206, connecting to New Orleans and Baton Rouge.

The highway was constructed in the early 1980s and involved re-routing and extending the existing Belle Terre Boulevard to I-10.

The original alignment curved northeast onto what is now Lakewood Drive, ending at the Belle Terre Country Club.

Just after crossing the Canadian National Railway (CN) tracks at grade, the highway intersects LA 641 (West Main Street).