Rexha released "I Can't Stop Drinking About You" as her debut single in 2014, followed by "I'm Gonna Show You Crazy", which was certified Platinum by the Swedish Recording Industry Association (GLF).

In 2015, Rexha collaborated with G-Eazy for her breakthrough single "Me, Myself & I", which experienced widespread success worldwide and was awarded multi-Platinum certifications in several countries.

She had also been featured on multiple other successful singles, including "Take Me Home" (2013) by Cash Cash, "Hey Mama" (2015) by David Guetta, "Back to You" (2017) by Louis Tomlinson, "Call You Mine" (2019) by the Chainsmokers, and "I'm Good (Blue)" (2022) with Guetta while having writing credits on various songs.

During 2020–2023 Rexha has released some notable singles as a solo musician as well as with guest vocalists from her friends within the industry baby!.

Most notable for her audience are; Baby, I'm Jealous" (2020) with featured vocal from Doja Cat, "Satellite" (2023) with Snoop Dogg and "One In A Million" (2023) with David Guetta.