She visits Graham in the Baltimore State Hospital for the Criminally Insane and tells him that she believes that Lecter framed him for murder.

[7] Eight months after fleeing the United States, Du Maurier and Lecter settle in Florence, Italy, where they pose as a married couple under the assumed names Lydia and Roman Fell.

[10][11] Three years later, Du Maurier makes her living from giving lectures on Lecter, presenting a story in which he drugged her into believing she was Lydia Fell.

[13] In the series finale, "The Wrath of the Lamb", Graham consults with Du Maurier on a plan to bait The Tooth Fairy, Francis Dolarhyde (Richard Armitage), by allowing Lecter to escape police custody.

She is last seen in a post-credits scene, sitting alone at a beautifully set dinner table and obviously under heavy sedation caused, most likely, by the same psychotropic drugs that she used upon herself in Italy.

Du Maurier remains seated, the very picture of elegance, with her hair perfectly coiffed and wearing a luxurious gown, all while the entrée, her impeccably prepared leg, is plated in front of her as the table’s centerpiece; in a similar manner to Lecter's victim Abel Gideon (Eddie Izzard).

As the camera zooms out, it is revealed that not only is the table set for three but it is also located in the same room of her home where she once conducted therapy sessions with Hannibal and where she killed her patient, Neal Frank.

When schedule conflicts prevented the hiring of Lansbury, Fuller decided on rewriting the character for a younger actress (Gillian Anderson).

After the airing of the second episode of season two, in which Du Maurier outsmarts Lecter, Fuller tweeted "Bedelia is the smartest character on the show".

That was a very important point for us to make with that storyline because I feel like we would be doing the actress and the character a disservice if we just made her a drug-induced pawn of Hannibal Lecter's plot".

[19] In another interview, he said that portraying Du Maurier as being in thrall to Lecter "would dishonour both the character and the actress [and] that's not how Gillian has been playing Bedelia".

[20] Vincenzo Natali, who directed four episodes of the third season, shared his perspective on the relationship between Du Maurier and Lecter, "From Bedelia's side, she's approaching it a little bit like a scientist – she's very much there to observe Hannibal in his natural habitat.

Anderson received a nomination of the 2013 Online Film & Television Association Award for Best Guest Actress in a Drama Series for her performance in the first season.