The series stars Rebecca Breeds as the titular character, along with Lucca De Oliveira, Devyn A. Tyler, Kal Penn, Nick Sandow, Michael Cudlitz, and Marnee Carpenter.

[26] Due to complicated rights issues of franchise characters between Metro-Goldwyn-Mayer and the Dino de Laurentiis Company, the series cannot feature or make reference to Hannibal Lecter.

Negotiations between ViacomCBS and co-producer MGM "stalemated", and since CBS had already committed to a full slate of shows, there was no space for Clarice to continue on network television.

Industry veterans described the state of affairs as "crazy", where a show already with a new season pickup is facing demise and the prospect of putting 300 people out of work, even though it involves a recognizable intellectual property and Kurzman, a top producer.

The website's critics consensus reads, "Effectively grim, but narratively bland, Clarice is a disturbingly safe procedural that lets down both its talented cast and source material.