Prinsloo recalled: "We went to the grocery store after church and this guy came up to me and asked if I was a model and wrote his number on a piece of paper...".

[47] Her ad campaigns include I Love Juicy Couture Fragrance,[48] I Am Juicy Couture Fragrance,[49] Juicy Couture Black Label,[50] Tommy Hilfiger,[51] Alexander Wang 'Do Something',[52] T by Alexander Wang,[53] Marc by Marc Jacobs,[18] H&M,[54] Nina Ricci,[55] The Gap,[56] Aquascutum,[57] M Missoni,[58] Sportmax,[59] DKNY Jeans,[60] Pepe Jeans,[61] Lancaster,[62] Stefanel,[63] Esprit,[64] Lacoste,[65] Desigual,[66] Seafolly,[67] Nine West,[68] and Raw Spirit Fragrance.

[73] The night before the 4 December 2012 airing of the annual Victoria's Secret Fashion Show, Prinsloo and fellow Victoria's Secret models Jacquelyn Jablonski and Jasmine Tookes guest starred on the 3 December "Ha'awe Make Loa" episode of CBS' Hawaii Five-0 playing themselves.

[74] In June 2014, Prinsloo made a cameo appearance in a preview of Missy Elliott protégée Sharaya J's "Shut It Down" via a T by Alexander Wang campaign.

[78] She was accompanied by a cameraman and his friend, and the resulting short film, Letters to Haiti, debuted 7 December 2011 at Milk Gallery in New York.

[79][78] She also supports Save the Rhino Trust, an organization trying to protect the black rhinoceros, a critically endangered species native to Namibia and other countries in Southern Africa.

[80] In 2012, Prinsloo began dating American musician Adam Levine of the group Maroon 5; they married in Mexico in 2014.