During the 1980s and 1990s, she was one of the most popular supermodels, being featured in the Sports Illustrated Swimsuit Issue and the cover of Vogue, as well as being a former Victoria's Secret Angel.

During the same period, Seymour was a primary lingerie and hosiery model for the relatively new Victoria's Secret company in its mail-order catalogs and retail stores.

[6] She was one of the most famous supermodels of the 1980s and 1990s along with Kate Moss, Naomi Campbell, Linda Evangelista, Christy Turlington, Helena Christensen, Cindy Crawford, and Claudia Schiffer.

Vanity Fair would later have several of these models appear on the cover of an issue photographed by Mario Testino, called "—A League Of Their Own".

The editors name famous models from previous decades, but explain that, "None of them attained the fame and worldwide renown bestowed on Linda Evangelista, Christy Turlington, Cindy Crawford, Naomi Campbell, Tatjana Patitz, Stephanie Seymour, Claudia Schiffer, Yasmeen Ghauri, and Karen Mulder in the late 1980s and early 1990s.

[9] Salvatore Ferragamo's creative campaign for his fall/winter 2007/2008 collection featured Seymour and Claudia Schiffer, shot on location in Italy with Mario Testino.

[10] Seymour was joined by other fellow supermodels Naomi Campbell, Kate Moss, Linda Evangelista, Daria Werbowy, Christy Turlington, and Amber Valletta for the September 2013 issue of Interview magazine titled "Model".

The line features high end vintage inspired pieces designed for comfort, ranging from camisoles and rompers to silk robes and nightgowns.

[13] Seymour's first acting role was as explosives expert Cynna Stone in the video game Hell: A Cyberpunk Thriller.

Shortly after her breakup with Rose, Seymour began dating businessman Peter Brant, who was married and the father of five children.