The building was designed in 1905 by the world-famous architect Victor Horta, in Art Nouveau style, and served as a textile department store, the Magasins Waucquez [fr].

[2] The second floor has a permanent exhibition dedicated to the chronological history of the medium in Belgium called "The Museum of Imagination".

[5] The exhibit starts off with Hergé and ends with Peyo, covering the pioneers of Belgian comics between 1929 and 1958 and with special focus on the magazines Spirou and Tintin.

[2] Four artists exhibited are Flemish: Willy Vandersteen, Marc Sleen, Bob de Moor and Morris.

On 30 January 2023, it was announced that the museum would close down in the autumn, with part of the collection being integrated into the Belgian Comic Strip Center.