The heart of the barrio pulses with life on its main thoroughfare, Avenida Cabildo, which runs Northwest to Southeast; the subway (subte) Line D follows its route.

Avenida Cabildo carries heavy automobile traffic, and features corner cafés, grocery stores, movie theaters, specialty shops, clothing boutiques, bookstores, and other retail venues.

Thanks to its wide sidewalks, pedestrians are especially numerous on weekend afternoons as Porteños (residents of Buenos Aires) from various areas of the city come to shop.

High-rise luxury apartment buildings are clustered on the leafy streets surrounding the Universidad de Belgrano, a private liberal-arts university.

West of Crámer avenue, "Belgrano R" is chiefly residential and lower-density in nature, characterized by calm streets lined with large, mature shade trees.

Most buildings in this section are detached single-family homes that follow North American architectural styles; some residences have sizable backyards with swimming pools.

This section is favored by wealthy Argentines and expatriate businesspeople, and also by the embassies of Egypt, Japan, Republic of Korea, Tunisia, United Arab Emitates, among others.

Approximately 1.5 km to the west of Belgrano lies Avenida General Paz, a major limited-access freeway that defines the city limits of Buenos Aires proper.

In the edge of the plaza lies the Inmaculada Concepción church, called "La Redonda" (the round one) by locals because of its circular plan.