They are currently led by head coach Scott Davenport and play their home games on campus at Knights Hall.

[7] It was on March 26, 2011, that the Knights won their first NCAA Division II National Championship, led by guards Jeremy Kendle and Braydon Hobbs.

[12][13] After a preseason shutdown due to the COVID-19 pandemic, the Knights played their first game at the Division I level on the road against the sixth-ranked Duke Blue Devils.

Two days after the loss to Duke, Bellarmine made a different kind of history for the program, which was undoubtedly more positive.

On December 6, 2020, the Knights traveled to the doorsteps of Howard University and dismantled the Bison 84–63 to notch their first ever win at the Division I level.

The Knights were so successful that their regular season finale against Liberty got moved to ESPNU, because it was a de facto winner-take-all game for the regular-season conference championship.

Held in Daytona Beach, Florida, Bellarmine defeated Army, 77–67, in the quarterfinals of the tournament, before falling short to Pepperdine, 82–71, in the semifinals.

Forward Pedro Bradshaw and guard Dylan Penn were honored for their outstanding seasons, as Bradshaw was the runner-up for ASUN Player of the Year and was a unanimous All-ASUN First Team selection, while Penn also earned All-ASUN First Team honors.

[15] On November 2, 2020, the university announced a multi-year deal with the Kentucky State Fair Board to use Freedom Hall, located at the Kentucky Exposition Center near Louisville Muhammad Ali International Airport, for men's and women's basketball home games.

Freedom Hall's basketball capacity of 18,252 allowed Bellarmine to seat 2,700 for games in its first D-I season.

[16] Bellarmine returned basketball to Knights Hall in 2024–25, coinciding with the end of the school's Division I transition.