Kenney played guitar for the hip-hop group the Roots before he joined Incubus in 2003 after the departure of the bass guitarist and founding member Alex Katunich (aka Dirk Lance).

He has also done studio work for artists including Justin Timberlake, Faith Evans, Erykah Badu, Musiq Soulchild, Glenn Lewis, Kindred the Family Soul, The Jazzyfatnastees, Jaguar Wright, Larry Gold and Blackalicious, and producers Timbaland, Dre & Vidal and DJ Jazzy Jeff.

26, Maduro, Distance and Comfort, Burn the Tapes, Leave On Your Makeup, and Must Be Nice were all released by Kenney's own record company, Ghetto Crush Industries.

Ghetto Crush has also released music for Ashley Mendel, The Division Group, Supergrub, Aleda and Root Valdez.

On January 21, 2025, after a nearly 2 year hiatus from social media, Kenney announced his new solo album Powerful Buttcheeks,[4] scheduled to release on March 3, 2025, along with a new single titled "Fires".

Although the surgery successfully removed the tumor, it caused complications such as leaving Kenney permanently deaf in one ear and partial facial paralysis.