[2] Prior to working for the Patriots, McAdoo had also served as an assistant coach for several college football teams, as well as for the New Orleans Saints, the San Francisco 49ers, Green Bay Packers, Jacksonville Jaguars, and Carolina Panthers.

McAdoo attended Indiana University of Pennsylvania (IUP) and earned a degree in health and physical education.

While attending Indiana University of Pennsylvania (IUP), McAdoo began working as an assistant high school coach in his sophomore year of college.

[3] In the 2001 season, McAdoo earned his first collegiate coaching position as a graduate assistant for special teams and offense.

[4][3] In 2003, McAdoo became a graduate assistant at the University of Pittsburgh under head coach Walt Harris and helped the team in the 2003 Continental Tire Bowl.

McAdoo was a member of the coaching staff of the 2010 Packers team that won Super Bowl XLV.

[6] On September 11, 2016, McAdoo won his first game as head coach when the Giants defeated the Dallas Cowboys 20–19.

After losing 24–17 to the Raiders and with the team sitting at 2–10, McAdoo was fired by the Giants on December 4, 2017, along with general manager Jerry Reese.

[9] On January 24, 2022, McAdoo was hired by the Carolina Panthers as their offensive coordinator under head coach Matt Rhule, replacing Joe Brady.