He was selected by the Green Bay Packers 16th overall in the 2007 NFL draft and was part of their Super Bowl XLV championship against the Pittsburgh Steelers.

Harrell attended Westview High School in Martin, Tennessee where his team was a state runner-up his senior year.

[7] Harrell took part in only limited drills with the Packers in their organized team activities (OTA) practices as a result of the torn biceps tendon suffered while playing for Tennessee.

Harrell immediately drew criticism for showing up to OTA and Training Camp his rookie season out of shape and slightly overweight.

On August 4, 2009, Harrell again injured his back during training camp practice and was inactive for the entire 2009 season.