Skowronek grew up in Fort Wayne, Indiana and attended Homestead High School.

[3] As a senior Skowronek caught 53 passes for 805 yards and nine touchdowns and was named first-team All-Indiana and was given the positional Mr. Indiana Football award.

He caught 12 passes for 141 yards in three games as a senior before suffering a season-ending leg injury and taking a medical redshirt.

[6] Following the end of his senior season, Skowronek announced he would be transferring to Notre Dame as a graduate student.

[16] In Super Bowl LVI, Skowronek had two receptions for 12 yards in the 23–20 victory against the Cincinnati Bengals.

In a 17–16 win over the Las Vegas Raiders in Week 14, Skowronek led the Rams with seven catches and 89 receiving yards.

He is a cousin of the Olympic gymnast Courtney Kupets, and former NFL quarterback Trent Green is an uncle by marriage.