In Alien Force, set five years after the original series, a now 15-year-old Ben Tennyson has retired from heroics until the sudden disappearance of Max, prompting him to re-equip the Omnitrix.

As past enemies resurface, including his archenemy Vilgax and the villainous Albedo, Ben ultimately relinquishes the Omnitrix , replacing it with the more advanced Ultimatrix.

The reboot returns to a traditional setting of Ben on summer vacation adventures with Gwen and Max, while featuring updated technology, new villains, and an overhauled animation style.

The series centers around Ben Tennyson (Tara Strong), a ten-year-old boy on a cross-country summer vacation with his cousin Gwen (Meagan Smith) and Grandfather Max (Paul Eiding).

During his first night camping in Max's RV, affectionately called "The Rustbucket," Ben ventures into a nearby forest and stumbles upon a crashed meteorite, which turns out to be an alien pod containing the Omnitrix.

With his newfound abilities, and later discovery of Max's past as part of a secret government organization called The Plumbers, Ben navigates through the responsibilities of being a hero.

Ben confronts more enemies and further expands his roster of aliens with the inclusion of Benwolf, Benmummy, Benviktor (renamed Blitzwolfer, Snare-Oh, and Frankenstrike in Omniverse), and Upchuck, while learning that the Omnitrix was originally intended for his grandfather.

In the Omniverse Flashbacks, which retroactively occur a year after the original series, Ben's roster of aliens continues to expand with the additions of Arctiguana, Spitter, and Feedback.

The Highbreed launch their galaxy-wide offensive across the universe, prompting Professor Paradox to bring Azmuth to Earth to inform Ben of the impending news.

Azmuth reinstates the master control in the Omnitrix, enabling Ben to utilize classic aliens like Cannonbolt, Way Big, and Upchuck in years.

The Alien Force travel to Augstaka, the Highbreed home world, where they learn that the species is facing extinction due to generations of inbreeding and plan to annihilate the universe as a result.

The Omnitrix utilizes the Nanochips to merge them with Ben's DNA to create the Nanomech transformation in order to intercept the queen and maintain independence from her hive.

Seeking revenge on the Alien Force for thwarting his previous attempts to steal the Omnitrix, Vilgax and Albedo form an unlikely alliance and preform abductions of Gwen and Kevin.

Ben has wielded the Ultimatrix for over a year since defeating Vilgax, and his secret identity has been revealed to the world by a young boy named Jimmy Jones.

Ben's newfound fame alters his life, as he is frequently smeared in the news by Will Harangue and is entangled with the celebrity world and media industry.

During this time, Ben's Ultimatrix scans each alien's DNA, adding transformations Water Hazard, Terraspin, NRG, Armodrillo, and AmFibian to the Ulitmatrix.

The Alien Force ventures to Mikd'Idty, Pissciss (Ripjaw's home world where the Ultimatrix reunlocks his DNA), Ledgerdomain, and Perplexahedron to collect the pieces of the Map of Infinity, but they fail each time as Aggregor secures them.

Professor Paradox suddenly returns and transports the Alien Force onto the Rust Bucket III ship en route to the Forge of Creation.

He unites the fragmented Forever Knights groups into a single organization with the goal of eliminating alien life on Earth, though this is a merely a diversion for the larger purpose of defeating Dagon upon his eventual return.

Albedo, also stranded on Earth, exploits Ben's newfound fame to raise funds for advanced machinery to revert him to his native Galvan form.

Ben, still familiarizing himself with the new Omnitrix, makes usage of his available transformations including new ones Astrodactyl, Ball Weevil, Bloxx, Crashhopper, Gutrot, Toepick and Gravattack.

After several encounters with the Faction in Undertown, Ben and Rook investigate an abandoned ship near Earth containing the Annihilargh, a doomsday device capable of erasing entire universes.

After defeating Eon and reversing his effects, Ben 10,000 appears and explains the conditions of the ongoing Time War to his younger self while mentioning the rouge Chronosapien, Maltruant.

After defeating Transyl and entrapping Zs'Skayr, it is revealed that Vilgax and Eon have formed a partnership and secretly recruit evil versions of Ben across the multiverse along with Albedo.

Ben, Rook, and Skurd along with Professor Paradox later face Maltruant and his minions in their attempts to retrieve the rebuilt Annhiliargh in the final stages of the Time War.

Later on, Ben and Kai try to stop Dr. Animo from using the Chronoporter from travelling back in time, but he succeeds but is quickly brought by Chrono-Spanner with the married couple remarking on how they haven't seen him in years.

In Crossover Nexus, Ben is brought to an alternate dimension and meets with heroes Garnet, K.O., and Teen Titans member Raven and must stop a mysterious villain dubbed Strike.

He further elaborates by mentioning that he had to replace Upgrade's spot in the Omnitrix with Shock Rock and the alien's DNA allowed it to absorb the excess charge which caused the creation of the Omni Enhancements.

This causes Grey Matter, Wildvine, and Overflow to be locked and replaced with aliens Rath, Slapback, and Humungousaur while the Omni Enhancements are no longer accessible.

Phill Billings gifts the Tennysons the Omni Copter to traverse around the world and they learn that Ben's old schooler Kevin Levin has his own version of the Omnitrix dubbed the Antitrix.