Other characters he has voiced include Yosemite Sam, Taz, Nikolai Belinski from Call of Duty Zombies, Soldier: 76, Shao Kahn, and Kakuzu.

Of Italian-American descent, Tatasciore is known for portraying characters with deep and powerful voices, though in recent years has expanded his range.

His best known video game roles include Damon Baird in the Gears of War series, Saren Arterius in the Mass Effect series, Zeratul in StarCraft II and Heroes of the Storm, Soldier: 76 in Blizzard's first-person shooter Overwatch and Xür in Bungie's first-person shooter Destiny.

He has also voiced Neftin Prog in Ratchet & Clank: Into the Nexus, Nikolai Belinski in the Call of Duty franchise, Megatron in Transformers: War for Cybertron, Fall of Cybertron, Dark of the Moon, and Rise of the Dark Spark, Tookit in ThunderCats and the Business Cat in the Cartoon Hangover web series Our New Electrical Morals administered by Frederator Studios.

In the Skylanders franchise, he voices Snap Shot, Slam Bam, Warnado, Strykore, Zook and Cuckoo Clocker.