Benedetto II Zaccaria (died 1330) was the co-Lord of Chios, as well as many other Aegean islands from 1314 until c. 1325.
Benedetto II was the cousin of Paleologo Zaccaria, and succeeded him in Chios and other lands in the Aegean Sea together with his brother Martino.
Benedetto asked for help from the Byzantine emperor, Andronikos III Palaiologos.
In 1329, Martin was declared deposed and captured by an imperial fleet of 105 ships sent to Chios.
However, after he died childless, the island was annexed to the Byzantine Empire.