She became Head of the Delegation of the Philippine Council of Young Political Leaders to the International Exchange Program of the Australian Political Exchange Council in Melbourne, Canberra and Sydney, Australia, and also became the co-head of the Philippine delegation and a resource person to the 8th International Conference of AIDS in Asia and the Pacific (ICAAP) held in Colombo, Sri Lanka.

As a councilor of Zamboanga City for two terms, she filed 858 council resolutions that advocated for women, family, youth, children, education, work and social welfare.

She was one of the authors of the House Bill seeking the Magna Carta for Women[4] in this Congress which was passed as a law August 2009.

Likewise, she also spearheaded the Lady Legislators of the 14th Congress, in launching Pink October, the first-ever breast cancer awareness and prevention campaign in the House of Representatives.

In her second term, Representative Maria Isabelle Climaco-Salazar was elected as House Deputy Speaker for Mindanao.

Her wedding coincided with the birthday of her late uncle Mayor Cesar C. Climaco[3] to honor the influence has had in her life.