In the 2000s, Bratt appeared in Miss Congeniality (2000), Traffic (2000), Piñero (2001), Catwoman (2004), Trucker (2008), Despicable Me 2 (2013), Snitch (2013), Coco (2017), among other films.

On television, Bratt has portrayed Dr. Jake Reilly on ABC's Private Practice (2011–2013), Steve Navarro on 24: Live Another Day (2014), and Jahil Rivera on Star (2016–2018).

Led by young people from San Francisco, it raised national awareness of issues facing Native Americans and attracted participants from across the country.

program at the American Conservatory Theater in San Francisco, he left before receiving his degree to star in the 1987 television film Juarez.

[6] Bratt started his professional acting career at the Utah Shakespeare Festival, where he starred in the television film Juarez.

This received critical acclaim, and he landed a supporting role in the television film Police Story: Gladiator School.

The following year, he played supporting roles in the popular films The River Wild, Clear and Present Danger, and James A. Michener's Texas.

Returning to television, he played Detective Reynaldo Curtis in the series Law & Order replacing Chris Noth, which gained him international recognition.

In 2009, Bratt returned as the now-retired Curtis on Law & Order, where he was reunited with his former boss, Lt. Anita Van Buren (S. Epatha Merkerson), in the episode that aired on December 11, 2009.

That same year, he played opposite Sandra Bullock in the romantic comedy Miss Congeniality and had a small role in the ensemble work Traffic.

In 2001, he starred in the biopic film Piñero, for which he received an American Latino Media Arts Award for Outstanding Actor in a Motion Picture.

He went on to say, "Whether you're talking about Miguel's sexuality or his time spent in jail or his petty crime or his drug addiction, each one of those things is a component that makes up the entirety of the man.

His later films include The Woodsman, Thumbsucker, The Great Raid, Trucker, Snitch, Ride Along 2, The Infiltrator, and Doctor Strange.

[6] In 2002, Bratt and Priscilla López received the Rita Moreno Award for Excellence from the Hispanic Organization of Latin Actors (HOLA).