[7] At SAB's 1994 Spring Workshop he originated a principal role in Jerome Robbins' premiere of 2 and 3 Part Inventions and also received the Prix de Lausanne.

[15] In 2012, L.A. Dance Project established a full-time residence at Los Angeles Theatre Center[16] with the objective of presenting new works throughout the city.

L.A. Dance Project's inaugural performance, commissioned by The Music Center was held at Walt Disney Concert Hall on 22 September 2012.

Later that year, Millepied and L.A. Dance Project dancer Amanda Wells performed a 30-minute duet entitled "Framework" at the Museum of Contemporary Art.

The dance collective's first program featured a Millepied premiere, Moving Parts, with a score by Muhly and visual design by painter Christopher Wool.

The program also includes a revival of Merce Cunningham's 1964 Winterbranch, a movement exploration of falling bodies set to a mostly two-note score by La Monte Young, and William Forsythe's Quintett, a 1993 study in loss and hope to avant-garde composer Gavin Bryar's composition Jesus' Blood Never Failed Me Yet.

[15] Millepied's collaborators include Rodarte, Barbara Kruger, and Alex Israel, a contemporary California painter and video artist.

[23] Millepied has commissioned and collaborated with contemporary composers including David Lang, Nico Muhly, Thierry Escaich, Daniel Ott, and Philip Glass.

[11][24] The Jerome Robbins Trust and Foundation has underwritten Millepied's work and donors include philanthropists Anne Bass and Arlene Cooper.

In 2009, he served as choreographer for Black Swan, a psychological thriller directed by Darren Aronofsky which stars Natalie Portman and Mila Kunis as ballet dancers in New York City.

[26] In 2010, he was the leading man in a short film co-directed by Asa Mader and starring Léa Seydoux, called Time Doesn't Stand Still.

He has directed a number of short films in collaboration with various artists, including Mark Bradford, Philip Glass, Io Echo, Zeds Dead, and Lil Buck.

[27] In 2014, Millepied became the Artistic Advisor of the new Dance Academy at the Colburn School in Downtown Los Angeles, joining fellow former-principal dancers with the New York City Ballet, Jenifer Ringer and James Fayette.