Wofford was ordained as a Methodist preacher, going on to preach in Kentucky, Tennessee, and South Carolina.
By 1807, he ran a farm and continued preaching locally in South Carolina.
Wofford was involved in various church charitable causes, including donating to Randolph-Macon College in Virginia during the 1830s.
Wofford married Anna Todd, the only child from a wealthy Spartanburg family, in 1807.
[1] Wofford died in 1850 and left a will donating $100,000 (~$2.84 million in 2023) for the creation of a college, which eventually became Wofford College, requesting the creation of a school "literary, classical, and scientific education in my native district of Spartanburg.".