His father, Eleazar Löw, instructed him in Talmudic literature, and at an early age he became rabbi of a Polish congregation.
In 1826 he was called as rabbi to Nagytapolcsány (Topoľčany), Royal Hungary, and in 1836 to Verbo (Vrbové), where he spent the remainder of his life.
Löw's son Jeremiah, rabbi in Sátoraljaújhely, was the recognized leader of the Orthodox party in Hungary and its spokesman in an audience which its deputation obtained with the Emperor in order to protest against the establishment of a rabbinical seminary.
Upon his death in 1872 he was succeeded by his son Eleazar, who was later called to the rabbinate of Unghvar (Uzhhorod).
Other grandsons of Wolf Löw were Abraham and Benjamin Singer, joint authors of Ha-Madrik, a pedagogic anthology of the Talmud.