Sa Beining was born in a military family in Zhanjiang, Guangdong in March 1976, the son of Dèng Yǎjuān (邓雅娟), a graduate of Shenyang Conservatory of Music, and Sǎ Shìguì (撒世贵), a Chinese actor in Wuhan Drama Theatre, he has a younger sister: Sǎ Bèinà (撒贝娜).

After graduation, he joined the China Central Television, he hosted Legal Report (今日说法), Shouxi Yehua (首席夜话), Insight (看见), and To Speak (开讲啦).

[2] Sa was selected to host the TV program Legal Report due to the recommendations of his instructors at the Peking University Law School, as a result of his many extra-curriculum experiences and high score.

In the second year after entering the China Central Television, he won the championship in the National TV Host Contest.

[7][8] In 2015, Sa was seen dating Canadian singer Lisa Marie Hoffman (known by her Chinese name 李白, Lǐ Bái).