Mayowa attended Inglewood High School, where as a senior defensive end, he had 75 tackles, 11 sacks, and one interception, while receiving All-league and second-team all-California Interscholastic Federation honors.

As a junior, he started 6 out of 10 games (missed 2 with an injury), posting 17 tackles (4.5 for loss), 3 sacks, 5 quarterback hurries, 2 passes defended, 2 forced fumbles and one recovered.

As a senior, he started 8 out of 11 games, making 22 tackles (7 for loss), 3 sacks, 4 quarterback hurries, one pass defended and 3 forced fumbles.

[8] Dallas looked towards Mayowa to provide depth at the defensive end position, with the looming suspensions to DeMarcus Lawrence and Randy Gregory, coupled with their decision not to bring back Greg Hardy.

He was placed on physically unable to perform list at the start of training camp, while recovering from a knee scope he underwent in June.

He returned to the lineup against the Minnesota Vikings, experiencing an improvement in his play, while finishing with 6 sacks (led the team), making 4 of them in the last five games.

Even though David Irving, Randy Gregory and Damontre Moore where suspended at the beginning of the regular season, Mayowa could not pass Tyrone Crawford on the depth chart at right defensive end.

[10] On April 23, 2018, Mayowa signed with the Arizona Cardinals, to provide depth while defensive end Markus Golden recovered from a torn ACL.