Bereina is a town in the Central Province of Papua New Guinea.

It is located on the Hiritano Highway about 160 kilometres (100 mi) north-west of Port Moresby, and contains the headquarters of both the Kairuku-Hiri District and the Kairuku Rural local-level government area.

Bereina also hosts a regional airport and a district town for the people of Kairuku Rural Area.

A short distance to the south is Mainohana Catholic High School, a De La Salle Year 9–12 school established in 1958.

Bereina has a tropical savanna climate (Köppen Aw) with heavy rainfall from December to April and moderate to little rainfall in the remaining months.