In 1899 she began her career designing clothing, specifically for the Vereeniging voor Verbetering van Vrouwenkleeding [nl] (the Dutch Society for the Improvement of Women's Dress).

[1] She taught at the Dagtekenschool voor meisjes [nl] (English:Day drawing school for girls) and the Koninklijke Academie van Beeldende Kunsten (The Hague) (Royal Academy of Art, The Hague).

Midderigh-Bokhorst continued her career, creating illustrations for children's books, magazines, fashion, and advertising.

Midderigh-Bokhorst worked through her life, her last book Glans en gloed uit donkere diepten was published in 1955.

In 1910 she was received a gold medal at the Brussels Exposition Universelle et Internationale for book decoration.