Berkeley High School is located in Moncks Corner, South Carolina, which is the county seat of Berkeley County.

The school serves 1,753 students from the towns and communities of: Moncks Corner, Cordesville, Lebanon, Longridge, MacBeth, Oakley, Pimlico, Santee Circle, and Whitesville.

Berkeley County's current population is approximately 221,091 with a racial composition of 64% Caucasian, 24% African American, 6% Hispanic, and 2% Asian.

Berkeley County has been one of the fastest growing communities in South Carolina.

The county's growth has presented a challenge for the Berkeley County School District and Berkeley High Schools: