Mukuamu grew up in Moncks Corner, South Carolina and originally attended Berkeley Senior High School.

As a sophomore in 2019, he was named the starter at safety for the season opener, before being moved to right cornerback opposite future NFL player Jaycee Horn.

He received second-team All-SEC honors after finishing with 13 starts, 59 tackles (2 for loss), four interceptions (led the team) and 9 pass breakups.

[7][8][9] He had a standout game in the 20-17 upset win against the third ranked University of Georgia, collecting 11 tackles and 3 interceptions, including one returned for a 53-yard touchdown.

On November 17, 2020, following the dismissal of head coach Will Muschamp, Mukuamu opted out of the remainder 3 games of the season to focus on his preparation for the 2021 NFL draft.